| 车次 | 出发站 | 开车时间 | 到达站 | 到达时间 |
| k593 | 开封 | 05:38 | 阜阳 | 09:26 |
| k596 | 开封 | 05:38 | 阜阳 | 09:26 |
| k133 | 开封 | 07:43 | 阜阳 | 11:56 |
| k132 | 开封 | 07:44 | 阜阳 | 11:56 |
| k743 | 开封 | 13:36 | 阜阳 | 17:22 |
| k742 | 开封 | 13:36 | 阜阳 | 17:22 |
| k1237 | 开封 | 15:20 | 阜阳 | 19:19 |
| k1240 | 开封 | 15:20 | 阜阳 | 19:19 |
| k29 | 开封 | 16:34 | 阜阳 | 20:13 |
| k32 | 开封 | 16:34 | 阜阳 | 20:13 |
| g1876 | 开封北 | 17:59 | 阜阳西 | 19:31 |
| g1873 | 开封北 | 17:59 | 阜阳西 | 19:31 |
| g1877 | 开封北 | 19:06 | 阜阳西 | 20:47 |
| g1880 | 开封北 | 19:06 | 阜阳西 | 20:47 |
| t328 | 开封 | 19:26 | 阜阳 | 23:38 |
| t325 | 开封 | 19:26 | 阜阳 | 23:38 |
| z146 | 开封 | 20:52 | 阜阳 | 23:29 |
| z147 | 开封 | 20:52 | 阜阳 | 23:29 |
| k605 | 开封 | 22:11 | 阜阳 | 02:10 |
| k608 | 开封 | 22:11 | 阜阳 | 02:10 |
| k61 | 开封 | 23:16 | 阜阳 | 03:29 |
| k60 | 开封 | 23:21 | 阜阳 | 03:29 |
| k2275 | 开封 | 23:58 | 阜阳 | 03:42 |
| k2278 | 开封 | 23:58 | 阜阳 | 03:42 |